Impaired adult myelination in the prefrontal cortex of socially isolated mice

Contact Information

Keywords

Patrizia Casaccia, patrizia.casaccia@mssm.edu

corticosterone; hippocampus; long-term depression (LTD); metaplasticity; social buffering; social transmission

Abstract

Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes of the prefrontal cortex (PFC) and impaired adult myelination. Social re-integration was sufficient to normalize behavioral and transcriptional changes. Short periods of isolation affected chromatin and myelin, but did not induce behavioral changes. Thus, myelinating oligodendrocytes in the adult PFC respond to social interaction with chromatin changes, suggesting that myelination acts as a form of adult plasticity.

Citation

Liu, J., Dietz, K., DeLoyht, J. M., Pedre, X., Kelkar, D., Kaur, J., ... & Casaccia, P. (2012). Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nature neuroscience, 15(12), 1621-1623.

DOI

10.1038/nn.3263

EWB Constructs:

positive affect, enrichment

EWB Measures:

N/A

data availability:

data availability details:

N/A

brain imaging paradigm:

electron microscopy

PFC

brain region/circuit:

Exclusion Criteria:

N/A

Inclusion Criteria

N/A

Non-EWB Behavioral
Measures:

N/A

First author:

Jia Liu

species:

mouse

sample size:

19-21

study design:

case control

longitudinal data?

younger controls?

N/A

interventions:

Socially re-intergrated socially isolated adult mice and examined re-myelination

study population:

N/A

sex (% female):

ethnicity (%white)

N/A

Age (mean, sd):

3-8 weeks

biological/Physiological Measures:

N/A