The objective of the Network for Emotional Well-being and Brain Aging (NEW Brain Aging) is to address mechanistic research on the role of emotional well-being(EWB) in health, identifying and testing mechanisms by which brain aging influences EWB, and how EWB may impact risk for and progression of Alzheimer's Disease and related dementias (ADRD). Synthesizing human and animal literature, our premise is that relationships between EWB and ADRD are bidirectional – normal and pathological changes in aging brain influence EWB and EWB contributes to brain health and illness, such as ADRD.