2022 Pilot Projects

"Self-generated thought as link between brain aging and emotional well-being"

Principal Investigator:

Objectives:

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Aim 1: Understand the brain networks associated with self generated thought (SGT) frequency and emotional valence. By utilizing a large, publicly available dataset with a one-time measure of SGT frequency and emotional valence during resting state fMRI scanning, we first aim to establish the FC associated with age-related differences in SGT frequency and emotional valence. 

 

Aim 2: Examine how day-to-day fluctuations in SGT frequency and emotional valence relate to experienced vs. evaluative EWB. We will probe participants about whether they are currently engaged in SGT (frequency) and what they are thinking about (content, including emotional valence), as well as questions about their mood (experienced EWB). We will measure evaluative EWB at baseline. 

Adam Turnbull, PhD
University of Rochester

Collaborators:

  • Kathi Heffner, PhD, University of Rochester

  • Jonathan Smallwood, PhD, Queen's University 

Abstract:

"The effect of heterochronic blood exchange on the emotion-related mesoscopic brain network in aged mice"

Principal Investigator:

Objectives:

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Aim  1:  Evaluate  how  social  isolation  affects  cortical  resting-state  functional  connectivity  in  aged  mice. 

Aim  2:  Evaluate  the  impact  of  young  blood  on  cortical  resting-state  functional  connectivity  in  aged  mice. 

Taken  together,  findings  from  our  proposed  studies  will  provide  a  neural  circuit-level  understanding of  the  effects  of  social  isolation  and  heterochronic  blood  exchange  on  the  aged  brain,  and  highlight potential  circuit  targets  for  rejuvenation  therapies. 

Ju Lu, PhD
University of California, Santa Cruz

Collaborators:

  • Irina Conboy, PhD, University of California Berkeley

Abstract: