Life satisfaction across the entire trajectory of Alzheimer's disease: A mediation analysis
Contact Information
Keywords
Arenda Mank, a.mank@amsterdamumc.nl
Alhzeimer’s disease, dementia, life satisfaction, mild cognitive impairment, mobility, subjective cognitive decline
Abstract
Introduction
We studied life satisfaction across Alzheimer's disease (AD) stages and studied mobility and meaningful activities as mediators of the associations between these AD stages and life satisfaction.
Methods
In this cross‐sectional study, we included n = 269 amyloid‐positive patients with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD dementia from the Amsterdam Dementia Cohort. Life satisfaction was measured with the satisfaction with life scale. The mediating role of transportation, work, sports, and hobbies on life satisfaction was examined in single and multiple mediator models.
Results
Patients with dementia are less satisfied with life compared to SCD and MCI. These differences in life satisfaction are explained by reduced participation in meaningful activities, which in turn, was largely attributable to decreased transportation use.
Discussion
Our findings suggest that improving access to transportation, therewith allowing participation in meaningful activities help to maintain life satisfaction and may be an important target for intervention.
Citation
Mank, A., van Maurik, I. S., van Harten, A. C., Rhodius‐Meester, H. F., Teunissen, C. E., van Berckel, B. N., ... & Rijnhart, J. J. (2022). Life satisfaction across the entire trajectory of Alzheimer's disease: A mediation analysis. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 14(1), e12389.
DOI
EWB Constructs:
(2) life satisfaction
EWB Measures:
Satisfaction with life scale (SWLS): Life Satisfaction
data availability:
No
data availability details:
N/A
brain imaging paradigm:
N/A
N/A
brain region/circuit:
Exclusion Criteria:
(1) diagnosis other than SCD, MCI, or dementia diagnosed at the follow‐up visits;
(2) not completing the questionnaire and therefore had no data on life satisfaction of the mediators.
Inclusion Criteria
(1) a diagnosis of AD dementia, MCI, or SCD;
(2) amyloid‐positive PET and/or cerebrospinal fluid (CSF) biomarkers;
(3) availability of data on life satisfaction, transportation, sports, hobbies and (voluntary) work.
Non-EWB Behavioral
Measures:
Transportation (three questions from the comprehensive geriatric assessment (CGA))
Hobbies (two questions)
Playing sports (two questions)
Continuing sports (playing sports at the time of completing the questionnaire)
Voluntary Work (two questions)
Maintaining voluntary work (doing voluntary work at the time of completing the questionnaire)
First author:
species:
human
sample size:
269
study design:
(1) cross-sectional
longitudinal data?
Yes
younger controls?
No
interventions:
N/A
study population:
(2) patients with (pre)clinical dementia
sex (% female):
50%
ethnicity (%white)
not stated
Age (mean, sd):
64.1 (6.9) for SCD, 67.3 (6.7) for MCI, 64.8 (7.0) for AD dementia
biological/Physiological Measures:
N/A